Invention Grant
- Patent Title: Inhibitors of influenza viruses replication
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Application No.: US15177546Application Date: 2016-06-09
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Publication No.: US09908878B2Publication Date: 2018-03-06
- Inventor: Paul S. Charifson , Michael P. Clark , Upul K. Bandarage , Randy S. Bethiel , Michael J. Boyd , Ioana Davies , Hongbo Deng , John P. Duffy , Luc J. Farmer , Huai Gao , Wenxin Gu , Joseph M. Kennedy , Brian Ledford , Mark W. Ledeboer , Francois Maltais , Emanuele Perola , Tiansheng Wang
- Applicant: Vertex Pharmaceuticals Incorporated
- Applicant Address: US MA Boston
- Assignee: Vertex Pharmaceuticals Incorporated
- Current Assignee: Vertex Pharmaceuticals Incorporated
- Current Assignee Address: US MA Boston
- Agency: Honigman Miller Schwartz and Cohn LLP
- Agent Andrew N. Weber; Jonathan P. O'Brien
- Main IPC: C07D471/04
- IPC: C07D471/04 ; A61K31/506 ; A61K45/06 ; C07F9/6561 ; A61K31/215 ; A61K31/351 ; A61K31/444 ; A61K31/497

Abstract:
Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A compound is represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.
Public/Granted literature
- US20160355512A1 INHIBITORS OF INFLUENZA VIRUSES REPLICATION Public/Granted day:2016-12-08
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