Invention Grant
- Patent Title: Monomeric CXCL121 peptide and methods of use thereof
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Application No.: US14736535Application Date: 2015-06-11
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Publication No.: US09908923B2Publication Date: 2018-03-06
- Inventor: Brian Volkman , Joshua Ziarek , Christopher Veldkamp , Francis Peterson
- Applicant: The Medical College of Wisconsin, Inc.
- Applicant Address: US WI Milwaukee
- Assignee: The Medical College of Wisconsin, Inc.
- Current Assignee: The Medical College of Wisconsin, Inc.
- Current Assignee Address: US WI Milwaukee
- Agency: Quarles & Brady LLP
- Main IPC: A61K38/19
- IPC: A61K38/19 ; C07K14/52 ; A61K38/00
Abstract:
The present invention provides a CXCL121 peptide engineered to resist peptide-induced dimerization by maintaining steric repulsion of the chemokine helix, pharmaceutical compositions thereof, and methods of using said dimer in the treatment of cancer, inflammatory disorders, autoimmune disease, and HIV/AIDS.
Public/Granted literature
- US20150361152A1 MONOMERIC CXCL121 PEPTIDE AND METHODS OF SYNTHESIS AND USE THEREOF Public/Granted day:2015-12-17
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