Invention Grant
- Patent Title: Collagen matrix with locally controlled intrafibrillar and extrafibrillar mineral content and methods of producing
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Application No.: US14169573Application Date: 2014-01-31
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Publication No.: US09908929B2Publication Date: 2018-03-06
- Inventor: Lester Smith , Stavros Thomopoulos
- Applicant: The Washington University
- Applicant Address: US MO Saint Louis
- Assignee: WASHINGTON UNIVERSITY
- Current Assignee: WASHINGTON UNIVERSITY
- Current Assignee Address: US MO Saint Louis
- Agency: Polsinelli PC
- Main IPC: C07K14/78
- IPC: C07K14/78 ; A61K38/39 ; A61L27/12 ; A61L27/24 ; A61L27/46
Abstract:
A mineralized collagen matrix with an intrafibrillar and/or extrafibrillar gradient of mineralization for insertion replacement is disclosed. The intrafibrillar mineralization of the collagen matrix is formed by the addition of fetuin to the simulated body fluid. The gradient of intrafibrillar mineralization may stiffen the collagen matrix and simulate a natural insertion for improved cell infiltration and regeneration.
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