Invention Grant
- Patent Title: Anti-human TSLP receptor antibody
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Application No.: US15090051Application Date: 2016-04-04
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Publication No.: US09908941B2Publication Date: 2018-03-06
- Inventor: Hiromu Sato , Daisuke Yamajuku , Kazunori Arai , Mako Ogino
- Applicant: Astellas Pharma Inc.
- Applicant Address: JP Tokyo
- Assignee: Astellas Pharma Inc.
- Current Assignee: Astellas Pharma Inc.
- Current Assignee Address: JP Tokyo
- Agency: Oblon, McClelland, Maier & Neustadt, L.L.P.
- Priority: JP2013-165676 20130809
- Main IPC: C07K16/28
- IPC: C07K16/28 ; C07K14/715 ; C12P21/02 ; C07K16/24 ; A61K39/00

Abstract:
An anti-human TSLP receptor antibody that specifically binds to human TSLP receptor and inhibits an action of human TSLP through human TSLP receptor. A method for preventing or treating asthma by administering the anti-human TSLP receptor antibody or an antigen-binding fragment thereof. An anti-human TSLP receptor antibody had been studied by the present inventors, and an anti-human TSLP receptor antibody including a heavy chain variable region consisting of the amino acid sequence of amino acid numbers 1 to 118 of SEQ ID NO: 1 and a light chain variable region consisting of the amino acid sequence of amino acid numbers 1 to 108 of SEQ ID NO: 3 was provided. It was revealed that the anti-human TSLP receptor antibody inhibits expression of TARC mRNA induced by TSLP and production of MDC proteins, and suppressed an allergic reaction in a monkey Ascaris antigen sensitization model.
Public/Granted literature
- US20160208005A1 NOVEL ANTI-HUMAN TSLP RECEPTOR ANTIBODY Public/Granted day:2016-07-21
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