Invention Grant
- Patent Title: Compounds and methods for modulating apolipoprotein C-III expression for improving a diabetic profile
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Application No.: US14900320Application Date: 2014-06-23
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Publication No.: US09909124B2Publication Date: 2018-03-06
- Inventor: Rosanne M. Crooke , Veronica J. Alexander
- Applicant: ISIS PHARMACEUTICALS, INC.
- Applicant Address: US CA Carlsbad
- Assignee: Ionis Pharmaceuticals, Inc.
- Current Assignee: Ionis Pharmaceuticals, Inc.
- Current Assignee Address: US CA Carlsbad
- Agency: Grant IP
- International Application: PCT/US2014/043723 WO 20140623
- International Announcement: WO2014/205449 WO 20141224
- Main IPC: C12N15/113
- IPC: C12N15/113 ; A61K31/155 ; A61K31/713
Abstract:
Provided herein are improved compounds, compositions and associated methods for reducing expression of ApoCIII mRNA and protein in a subject having, or at risk of having, diabetes. Also provided herein are compounds, compositions and associated methods improving peripheral insulin sensitivity, a lipid profile and a diabetes profile as well as reducing free fatty acids and intramyocellular triglyceride deposition.
Public/Granted literature
- US20160152974A1 COMPOUNDS AND METHODS FOR MODULATING APOLIPOPROTEIN C-III EXPRESSION FOR IMPROVING A DIABETIC PROFILE Public/Granted day:2016-06-02
Information query
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