Method for the determination of the concentration of a type of specific nucleic acids (10) in a sample, wherein the sequences of the specific nucleic acid (10) at least partially match a reference sequence, and/or for the determination of the degree of the match of the sequences of specific nucleic acids (10) of a type in a sample (9) and a reference sequence, comprising the following steps: providing a first probe (1), which possesses a first oligonucleotide (3) on its surface; providing a second oligonucleotide (7), which is partially complementary to the first oligonucleotide (3) or to a first oligonucleotide adapter (20), which is partially complementary to the first oligonucleotide (3), and wherein the second oligonucleotide (7) is partially complementary to the reference sequence; combining of the first probe (1) and the second oligonucleotide (7) and—if applicable—the first oligonucleotide adapter (20) with the sample (9), wherein a specific nucleic acid (10) contained in the sample (9) can hybridize with the second oligonucleotide (7) and the second oligonucleotide (7) is activated by the hybridization.