An engine control system and method of reducing knocking combustion in a spark-ignited internal combustion engine having exhaust gas recirculation by controlling engine timing based on detection of a misfire in an engine cylinder. The engine control system determines a number of combustion cycles indicative of an amount of time that will pass before misfire gas from the detected misfire will be recirculated to a combustion chamber of any cylinder of the internal combustion engine, and the engine control unit reduces or prevents knocking combustion by adjusting the ignition timing of at least one subsequent combustion cycle after the determined number of combustion cycles have occurred since the misfire was detected.