The subject matter described herein relates to methods, systems, and computer readable media for adaptive calibration of test systems to interconnects. In some examples, a control circuit performs a method for adaptive calibration including determining, for each configurable calibration parameter of a number of configurable calibration parameters for a receiver for processing a received signal from an interconnect coupled to the receiver, a range of valid values for the configurable calibration parameter. The method further includes for each configurable calibration parameter: sweeping the configurable calibration parameter across a subset of values from the range of valid values for the configurable calibration parameter; and testing the received signal from the interconnect for each value in the subset of values and storing a result of the testing for the value. The method further includes determining a set of calibrated values for the configurable calibration parameters based on the results of the testing.