Examples herein relate to circuits for computing vector-matrix multiplications involving negative values. A first memory crossbar array may be mapped to a first matrix which includes the positive values of an input matrix. A second memory crossbar array may be mapped to a second matrix which includes the negative values of the input matrix. An analog-to-digital converter may generate digital intermediate multiplication results based on analog results computed by the memory crossbar arrays. The digital intermediate multiplication results may include an intermediate result corresponding to a multiplication of each of the first vector and second vector with each of the first matrix and the second matrix. A controller may aggregate the digital intermediate results to generate a combined multiple result that represents the vector-matrix multiplication of the input vector and the input matrix.