A method for enabling coexistence of multiple communication modes in mobile terminal and a mobile terminal thereof are provided. The method includes: when the mobile terminal is currently working in a first communication mode, if the mobile terminal receives a first signal of a second communication mode in a first frequency band, determining whether to continue working in the first communication mode or to shift to work in first frequency band of the second communication mode based on a preset priority rank. Accordingly, interferences between multiple wireless communication modes in a mobile terminal can be reduced.