Apparatus and methods are provided for TDM uplink transmission on multiple serving cells with single transmitter. In one novel aspect, the UE selects a serving cell for an UL transmission subframe based on a TDM selection rule. In one embodiment, the switching rule involves identifying one or more serving cells with a highest UL transmission priority and a serving-cell priority rule. In another novel aspect, the UE drops a selected part of the UL transmission within the overlap region based on one or more switching rules, which include dropping a last OFDM symbol, dropping a portion of a last OFDM symbol of the SRS with combing structure, dropping a partial CP of a first OFDM symbol of the second serving cell, and dropping a partial tail of a last OFDM symbol of the first serving cell and partial CP of a first OFDM symbol of the second serving cell.