Invention Grant
- Patent Title: Consensus prostate antigens, nucleic acid molecule encoding the same and vaccine and uses comprising the same
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Application No.: US15207271Application Date: 2016-07-11
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Publication No.: US09913885B2Publication Date: 2018-03-13
- Inventor: David Weiner , Jian Yan , Bernadette Ferraro , Niranjan Y. Sardesai , Mathura P. Ramanathan
- Applicant: The Trustees of the University of Pennsylvania , Inovio Pharmaceuticals, Inc.
- Assignee: INOVIO PHARMACEUTICALS, INC.,THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
- Current Assignee: INOVIO PHARMACEUTICALS, INC.,THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
- Agency: Riverside Law LLP
- Main IPC: C07K14/00
- IPC: C07K14/00 ; A61K39/00 ; C12N9/48 ; C12N9/64 ; C07K14/47
Abstract:
Provided herein are consensus amino acid sequences of prostate antigens that are capable of breaking tolerance in a targeted species, including PSA, PSMA, STEAP and PSCA antigens. Also provided are nucleic acid sequences that encode one or more consensus amino acid sequences of prostate antigens PSA, PSMA, STEAP and PSCA, as well as genetic constructs/vectors and vaccines expressing the sequences. Also provided herein are methods for generating an autoimmune response against prostate cancer cells by administering one or more of the vaccines, proteins, and/or nucleic acid sequences that are provided.
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