Invention Grant
- Patent Title: Heteroaryl Syk inhibitors
-
Application No.: US15027518Application Date: 2015-03-12
-
Publication No.: US09914735B2Publication Date: 2018-03-13
- Inventor: Georg Dahmann , Matthias Hoffmann , Jasna Klicic , David James Lamb , Clive McCarthy , Spencer Charles R. Napier , Karen Parrish , John Scott , Jennifer L. Swantek Fitzgerald , Edward Walker
- Applicant: Boehringer Ingelheim International GmbH
- Applicant Address: DE Ingelheim am Rhein
- Assignee: Boehringer Ingelheim International GmbH
- Current Assignee: Boehringer Ingelheim International GmbH
- Current Assignee Address: DE Ingelheim am Rhein
- Agent Marc Began; Philip I. Datlow
- International Application: PCT/EP2015/055228 WO 20150312
- International Announcement: WO2015/140051 WO 20150924
- Main IPC: A61K31/4184
- IPC: A61K31/4184 ; C07D487/04 ; C07D413/12 ; C07D417/12 ; C07D498/04 ; C07D513/04 ; A61K31/416 ; A61K31/427 ; A61K31/437 ; A61K31/444 ; A61K31/454 ; A61K31/4545 ; A61K31/496 ; A61K31/5377 ; A61K31/55 ; A61K45/06 ; C07D401/14 ; C07D403/12 ; C07D403/14 ; C07D417/14 ; C07D471/04 ; C07D519/00 ; A61K31/519

Abstract:
The invention relates to new substituted heteroaryls of formula (1), wherein A is selected from the group consisting of N and CH, D is CH, E is selected from the group consisting of C and N, T is C, G is selected from the group consisting of C and N, and wherein each of the broken (dotted) double bonds in ring 1 are selected from either a single bond or a double bond under the proviso that all single and double bonds of ring 1 are arranged in such a way that they all form together with ring 2 an aromatic ring system, and wherein R1, M and R3 are defined according to claim 1, and to the above compounds for the treatment of a disease selected from the group consisting of asthma, COPD, allergic rhinitis, allergic dermatitis, lupus erythematodes, lupus nephritis and rheumatoid arthritis.
Public/Granted literature
- US20160244446A1 HETEROARYL SYK INHIBITORS Public/Granted day:2016-08-25
Information query
IPC分类: