A method for operating an internal combustion engine (10) that has at least one cylinder row (11a, 11b) with first and second exhaust-gas turbochargers (13a, 13b; 14a, 14b). Charge air is provided by the first exhaust-gas turbocharger (13a, 13b) in single-charger operation, but is provided by the first and second exhaust-gas turbocharger (13a, 13b; 14a, 14b) in two-charger operation. To switch from single-charger to two-charger operation above a load threshold value of the internal combustion engine (10), when a speed of the internal combustion engine (10) reaches or overshoots a threshold value, a charge pressure is increased to build up a torque reserve and a charge pressure reserve and to maintain a driver demand torque. When the charge pressure reaches or overshoots a threshold value, a switch is made from single-charger operation to two-charger operation, and subsequently, the torque reserve and the charge pressure reserve are eliminated.