Invention Grant
- Patent Title: Protein microarray for characterizing the specificity of the monoclonal immunoglobulins of MGUS or myeloma patients
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Application No.: US14416890Application Date: 2013-07-23
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Publication No.: US09915662B2Publication Date: 2018-03-13
- Inventor: Edith Bigot-Corbel , Sylvie Hermouet , Delphine Feron , Cathy Charlier , Pierre Weigel , Adrien Herlédan , Yannick Jacques
- Applicant: Sylvie Hermouet , Edith Bigot-Corbel , Delphine Feron
- Applicant Address: FR Nantes FR Montfaucon-Montigné FR Pont-Saint-Martin
- Assignee: Sylvie Hermouet,Edith Bigot-Corbel,Delphine Feron
- Current Assignee: Sylvie Hermouet,Edith Bigot-Corbel,Delphine Feron
- Current Assignee Address: FR Nantes FR Montfaucon-Montigné FR Pont-Saint-Martin
- Agency: Stites & Harbison, PLLC
- Agent B. Aaron Schulman, Esq.
- Priority: EP12305896 20120723
- International Application: PCT/EP2013/065524 WO 20130723
- International Announcement: WO2014/016301 WO 20140130
- Main IPC: G01N33/577
- IPC: G01N33/577 ; B01J19/00 ; G01N33/569 ; G01N33/574 ; G01N33/576 ; G01N33/68
Abstract:
The present invention concerns materials and methods for characterizing monoclonal immunoglobulin specificity of a Monoclonal Gammopathy of Undetermined Significance (MGUS) or Myeloma patients using a protein microarray comprising (a) a substrate, (b) antigens immobilized on the substrate, said antigens being selected from a defined group consisting of infectious agent antigens and/or self-antigens. In particular said protein microarray may be used to improve diagnosis, for the prognosis of myeloma or MGUS, for preventing transformation of MGUS toward myeloma, for adapting treatment of MGUS and myeloma or for monitoring the response to therapy of MGUS and myeloma patients.
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