The invention is directed to systems and methods for detecting the loss, theft or unauthorized use of a device and/or altering the functionality of the device in response. In one embodiment, a method includes detecting that a security compromise event has occurred for a mobile device. The method also includes altering a function of the mobile device in response to the security compromise event to mitigate loss of control by an authorized user. Altering the function of the mobile device includes denying access to data stored on the mobile device.