The embodiments relate to a method and a base station (110) for interference management in a cellular network (100) employing Space-Division uplink (UL) downlink (DL) Duplexing (SDD). The base station (110) assigns a plurality of Remote Radio Units (RRU) as Tx RRUs operable to dedicatedly transmit downlink signals to a plurality of UEs and Rx RRUs operable to dedicatedly receive uplink signals from the plurality of UEs at the same frequency band and same time as the transmission of the Tx RRUs. The base station then suppresses the interference caused by simultaneous transmission on the same frequency band by using a Tx spatial beamforming weighting matrix and a Rx spatial beamforming weighting matrix. In addition, the base station may perform cross-talk cancellation on the residual interference contained in the received signals by using the knowledge of the downlink traffic data.