Example embodiments may help multi-camera devices determine disparity information scene, and use the disparity information in an autofocus process. An example method involves: (a) receiving image data of a scene that comprises at least one image of the scene captured by each of two or more image-capture systems of a computing device that includes a plurality of image-capture systems; (b) using the image data captured by the two or more image-capture systems as a basis for determining disparity information for the scene; and (c) performing, by the computing system, an autofocus process based at least in part on the disparity information, wherein the autofocus process provides a focus setting for at least one of the image-capture systems of the computing device.