A method is provided in one example embodiment and may include determining one or more uplink inter cell interference coordination (ICIC) parameters for a plurality of cells based, at least in part, on feedback information associated with the plurality of cells; exchanging interference information between neighboring cells; and scheduling uplink transmissions for user equipment served by the neighboring cells based, at least in part, on the uplink ICIC parameters and the interference information exchanged between neighboring cells. A method is provided in another example embodiment and may include determining a ratio relating a first portion of a frequency spectrum for assigning fractional frequency re-use resources to a second portion of the frequency spectrum for assigning re-use one resources; and updating the ratio relating the first portion and the second portion of the frequency spectrum to optimize throughput rates for the plurality of user equipment across the plurality of cells.