Invention Grant
- Patent Title: Stabilized pharmaceutical composition
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Application No.: US12161787Application Date: 2007-02-22
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Publication No.: US09931295B2Publication Date: 2018-04-03
- Inventor: Hayato Ishimoto , Tsutomu Harada , Hiroshi Omae
- Applicant: Hayato Ishimoto , Tsutomu Harada , Hiroshi Omae
- Applicant Address: JP Tokyo
- Assignee: Eisai R&D Management Co., Ltd.
- Current Assignee: Eisai R&D Management Co., Ltd.
- Current Assignee Address: JP Tokyo
- Agency: Fish & Richardson P.C.
- Priority: JP2006-045569 20060222
- International Application: PCT/JP2007/053246 WO 20070222
- International Announcement: WO2007/097386 WO 20070830
- Main IPC: A61K9/20
- IPC: A61K9/20 ; A61K31/675 ; A61K47/02 ; A61K47/18 ; A61K9/00 ; A61K31/4196 ; A61K31/4439

Abstract:
It is an object of the present invention to provide a pharmaceutical composition containing a stable azole-based compound, which is useful as an antifungal agent. According to the present invention, the above-mentioned object can be achieved by adding magnesium hydroxide carbonate, triethylamine, arginine, or another such basic substance to an azole-based compound that is unstable in acids. The above-mentioned pharmaceutical composition is stable enough that the compound will not degrade if the temperature, humidity, or other such conditions should change during production or storage. Also, this composition is useful as a therapeutic agent for deep mycoses because systemic administration is possible by applying it to an oral agent or an injection.
Public/Granted literature
- US20100249426A1 STABILIZED PHARMACEUTICAL COMPOSITION Public/Granted day:2010-09-30
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