Invention Grant
- Patent Title: Cell expressing complexes of IL-15 and IL-15Ralpha
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Application No.: US12666052Application Date: 2008-06-27
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Publication No.: US09931377B2Publication Date: 2018-04-03
- Inventor: George N. Pavlakis , John N. Vournakis , Barbara K. Felber , Sergio Finkielsztein
- Applicant: George N. Pavlakis , John N. Vournakis , Barbara K. Felber , Sergio Finkielsztein
- Applicant Address: US DC Washington CH Basel
- Assignee: The United States of America, as Represented by the Secretary, Department of Health and Human Services,Novartis AG
- Current Assignee: The United States of America, as Represented by the Secretary, Department of Health and Human Services,Novartis AG
- Current Assignee Address: US DC Washington CH Basel
- Agent David A. Carpenter
- International Application: PCT/US2008/008084 WO 20080627
- International Announcement: WO2009/002562 WO 20081231
- Main IPC: C12N5/10
- IPC: C12N5/10 ; A61K38/20 ; A61K39/00 ; A61K38/17
Abstract:
The present invention relates to agents that modulate interleukin-15 (“IL-15”) signal transduction or function (“Therapeutic Agents”) and the use ol″ those agents to modulate immune function. The Therapeutic Agents target the interaction between IL-15 and its receptor and modulate IL-15-induced signal transduction. The Therapeutic Agents may be formulated with polymers, such as poly-β-1-♦4-N-acetylglucosamine. for administration to a human subject to modulate IL-15-mediated immune function.
Public/Granted literature
- US20110081311A1 COMPLEXES OF IL-15 AND IL-15RALPHA AND USES THEREOF Public/Granted day:2011-04-07
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