Invention Grant
- Patent Title: Chemical compound for inhibition of SHP2 function and for use as an anti-cancer agent
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Application No.: US15371699Application Date: 2016-12-07
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Publication No.: US09932288B2Publication Date: 2018-04-03
- Inventor: Yehenew Agazie , Zachary Hartman
- Applicant: West Virginia University
- Applicant Address: US WV Morgantown
- Assignee: West Virginia University
- Current Assignee: West Virginia University
- Current Assignee Address: US WV Morgantown
- Agency: Buchanan Ingersoll & Rooney PC
- Main IPC: C07C57/34
- IPC: C07C57/34 ; C07C51/09 ; C12N5/09 ; G01N33/50

Abstract:
This invention provides a compound that is 4,4′-(4′-Carboxy)-4-nonyloxy-[1,1′-biphenyl]-3,5-diyl)dibutanoic acid (CNBDA), derivative compounds of CNBDA, and pharmaceutical compositions thereof. The derivative compounds of CNBDA have one or more of the following substitutions (a) replacement of one or both of the carboxylic acid groups of the CNBDA compound with an organic acid group having 1-3, or 5-30, or more carbon atoms in chain length, wherein the carbon atom chains are either saturated, partially saturated, or unsaturated with respect to the carbon to carbon bonding, (b) replacement of the carboxylic groups of (a) with a phosphate, a sulphate, an amide, a hydroxyl, an aldehyde, or a halide group, and (c) replacement of the nonane group with an alkane having a carbon chain length of 1-8 or 10-30, or more carbon atoms. A method of treating a patient having cancer is provided.
Public/Granted literature
- US20170166510A1 Chemical Compound for Inhibition of SHP2 Function and for Use as an Anti-Cancer Agent Public/Granted day:2017-06-15
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