Invention Grant
- Patent Title: Antidiabetic tricyclic compounds
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Application No.: US15023124Application Date: 2014-09-30
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Publication No.: US09932311B2Publication Date: 2018-04-03
- Inventor: Tesfaye Biftu , Purakkattle Biju , Steven L. Colletti , Mingxiang Cui , William K. Hagmann , Bin Hu , Hubert Josien , Nam Fung Kar , Anilkumar Nair , Ravi Nargund , Donald M. Sperbeck , Cheng Zhu
- Applicant: Merck Sharp & Dohme Corp.
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Baerbel R. Brown; Catherine D. Fitch
- Priority: WOPCT/CN2013/084846 20131008
- International Application: PCT/CN2014/087857 WO 20140930
- International Announcement: WO2015/051725 WO 20150416
- Main IPC: C07D221/16
- IPC: C07D221/16 ; C07D401/12 ; C07D405/12 ; C07D405/14 ; A61K31/435 ; A61K31/444 ; A61K45/06

Abstract:
Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.
Public/Granted literature
- US20160207887A1 ANTIDIABETIC TRICYCLIC COMPOUNDS Public/Granted day:2016-07-21
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