- Patent Title: Phenyl tetrahydroisoquinoline compound substituted with heteroaryl
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Application No.: US15328223Application Date: 2015-07-24
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Publication No.: US09932331B2Publication Date: 2018-04-03
- Inventor: Shoichi Kuroda , Kenichi Kawabe , Yasunobu Ushiki , Hiroshi Ohta , Fumito Uneuchi , Tsuyoshi Shibata , Hideaki Tabuse , Eiji Munetomo , Sumi Chonan
- Applicant: TAISHO PHARMACEUTICAL CO., LTD
- Applicant Address: JP
- Assignee: TAISHO PHARMACEUTICAL CO., LTD.
- Current Assignee: TAISHO PHARMACEUTICAL CO., LTD.
- Current Assignee Address: JP
- Agency: Finnegan, Henderson, Farabow, Garrett & Dunner, LLP
- Priority: JP2014-151726 20140725; JP2015-051289 20150313
- International Application: PCT/JP2015/071111 WO 20150724
- International Announcement: WO2016/013657 WO 20160128
- Main IPC: C07D417/10
- IPC: C07D417/10 ; C07D401/10 ; C07D413/10 ; C07D405/10 ; C07D401/14 ; C07D413/14

Abstract:
The present invention provides a compound represented by the following formula [1] or a pharmaceutically acceptable salt thereof which has an excellent NHE3 inhibitory effect: A-Y [1] wherein A represents a structure represented by the following formula [2]: wherein R11 and R12 each represent a halogen atom or others as described herein, R2 represents C1-6 alkyl or others as described herein, ring E represents triazole, tetrazole, pyrimidine, or others as described herein, R31 and R32 each represent a hydrogen atom, C1-6 alkyl, C1-6 alkoxy, or others as described herein, and W represents a single bond, the formula —NH—, the formula —O—, or the formula —CONH—, and Y represents a hydrogen atom or a structure selected from
Public/Granted literature
- US20170210736A1 PHENYL TETRAHYDROISOQUINOLINE COMPOUND SUBSTITUTED WITH HETEROARYL Public/Granted day:2017-07-27
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