Invention Grant
- Patent Title: Fused tricyclic benzimidazoles derivatives as modulators of TNF activity
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Application No.: US15102003Application Date: 2014-12-08
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Publication No.: US09932343B2Publication Date: 2018-04-03
- Inventor: Rikki Peter Alexander , Mark Daniel Calmiano , Sabine Defays , Veronique Durieu , Michael Deligny , Jag Paul Heer , Victoria Elizabeth Jackson , Jean Keyaerts , Boris Kroeplien , Malcolm Mac Coss , Yogesh Anil Sabnis , Matthew Duncan Selby , Dominique Louis Leon Swinnen , Nathalie Van Houtvin , Zhaoning Zhu , Uwe Heinelt , Volkmar Wehner
- Applicant: UCB BIOPHARMA SPRL
- Applicant Address: BE Brussels
- Assignee: UCB BIOPHARMA SPRL
- Current Assignee: UCB BIOPHARMA SPRL
- Current Assignee Address: BE Brussels
- Agency: McDonnell Boehnen Hulbert & Berghoff LLP
- Priority: GB1321728.6 20131209
- International Application: PCT/EP2014/076880 WO 20141208
- International Announcement: WO2015/086525 WO 20150618
- Main IPC: A61K31/415
- IPC: A61K31/415 ; A61K31/495 ; A61K31/44 ; A61K31/425 ; C07D403/02 ; C07D487/00 ; C07D513/00 ; C07D491/00 ; C07D498/02 ; C07D487/04 ; A61K31/4188 ; C07D471/04 ; C07D498/04 ; C07D519/00 ; C07D513/04
Abstract:
A series of tricyclic benzimidazole derivatives, in particular dihydro-1H-imidazo [1,2-a]benzimidazole, dihydro-1H-pyrrolo [1,2-a]benzimidazole, dihydro-1H-pyrazino[1,2-a]benzimidazole, dihydro-1H-[1,4]oxazino[4,3-a]benzimidazole and dihydrothiazolo[3,4-a]benzimidazolem, and analogs thereof, being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
Public/Granted literature
- US20160304523A1 Fused Tricyclic Benzimidazoles Derivatives As Modulators of TNF Activity Public/Granted day:2016-10-20
Information query
