Invention Grant
- Patent Title: Antisense-based small RNA agents targeting the Gag open reading frame of HIV-1 RNA
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Application No.: US14912100Application Date: 2014-08-25
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Publication No.: US09932364B2Publication Date: 2018-04-03
- Inventor: Anne Gatignol , Robert Scarborough
- Applicant: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
- Applicant Address: CA Montreal
- Assignee: The Royal Institution for the Advancement of Learning/McGill University
- Current Assignee: The Royal Institution for the Advancement of Learning/McGill University
- Current Assignee Address: CA Montreal
- Agent Alain Dumont
- International Application: PCT/CA2014/050814 WO 20140825
- International Announcement: WO2015/027334 WO 20150305
- Main IPC: C07H21/04
- IPC: C07H21/04 ; C07H21/02 ; C12N15/113
Abstract:
Antisense nucleic acid molecules, such as ribozymes, shRNA and siRNA, targeting the Gag region of HIV-1 open reading frame, and uses thereof for inhibiting HIV-1 replication and infection, are disclosed. The antisense nucleic acid molecules more specifically target a sequence corresponding to about nucleotide 1495 to about nucleotide 1526, or nucleotide 1497 to about nucleotide 1521, of HIV-1 clone pNL4-3.
Public/Granted literature
- US20160201061A1 ANTISENSE-BASED SMALL RNA AGENTS TARGETING THE GAG OPEN READING FRAME OF HIV-1 RNA Public/Granted day:2016-07-14
Information query
