Invention Grant
- Patent Title: Stabilized mosaic human immunodeficiency virus type 1 (HIV-1) GP140 envelope (ENV) trimers
-
Application No.: US14149549Application Date: 2014-01-07
-
Publication No.: US09932370B2Publication Date: 2018-04-03
- Inventor: Dan H. Barouch , Joseph Patrick Nkolola
- Applicant: Beth Israel Deaconess Medical Center, Inc.
- Applicant Address: US MA Boston
- Assignee: Beth Israel Deaconess Medical Center, Inc.
- Current Assignee: Beth Israel Deaconess Medical Center, Inc.
- Current Assignee Address: US MA Boston
- Agency: Panitch Schwarze Bellisario & Nadel LLP
- Main IPC: A61K39/21
- IPC: A61K39/21 ; C07K14/005 ; C07K14/16 ; A61K39/12 ; A61K39/00
Abstract:
The invention features isolated human immunodeficiency virus (HIV) envelope (Env) trimers, in which the amino acid sequence of the Env polypeptides is optimized to stabilize formation of the trimers. The invention also features vaccines, nucleic acids, and vectors to deliver and/or facilitate production of the stabilized HIV Env trimers. In addition, the invention features methods of making and using the stabilized HIV Env trimers of the invention.
Public/Granted literature
- US20140302080A1 STABILIZED HUMAN IMMUNODEFICIENCY VIRUS (HIV) ENVELOPE (ENV) TRIMER VACCINES AND METHODS OF USING SAME Public/Granted day:2014-10-09
Information query
