- Patent Title: Single chain intrabodies that alter huntingtin mutant degradation
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Application No.: US14731353Application Date: 2015-06-04
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Publication No.: US09932394B2Publication Date: 2018-04-03
- Inventor: Lee Alan Henderson , Irene Alexandra Amaro
- Applicant: Vybion, Inc.
- Applicant Address: US NY Ithaca
- Assignee: Vybion, Inc.
- Current Assignee: Vybion, Inc.
- Current Assignee Address: US NY Ithaca
- Agency: Fenwick & West LLP
- Main IPC: C07K16/18
- IPC: C07K16/18 ; A61K39/00
Abstract:
Compositions and methods of use are provided for intrabodies that bind and alter the effects of poly-glutamate protein aggregation in poly-glutamate associated diseases, such as in Huntington's disease. Intrabodies are provided that prevent poly-glutamate aggregation, gene dysregulation, and negative effects of Huntington's disease.
Public/Granted literature
- US20170044241A1 Single Chain Intrabodies that Alter Huntingtin Mutant Degradation Public/Granted day:2017-02-16
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