Invention Grant
- Patent Title: Method for in vitro differentiation of blood circulating cells into neuronal-like cells and applications thereof
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Application No.: US14515884Application Date: 2014-10-16
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Publication No.: US09932556B2Publication Date: 2018-04-03
- Inventor: Anne Hosmalin , Vincent Feuillet , Marie-Odile Krebs , Thérèse Jay , Alfredo Bellon
- Applicant: Centre National de la Recherche Scientifique (CNRS) , Universite Paris Descartes , Institut National De La Sante Et De La Recherche Medicale (INSERM) , Assistance Publique—Hopitaux De Paris
- Applicant Address: FR Paris FR Paris FR Paris FR Paris
- Assignee: Centre National de la Recherche Scientifique (CNRS),Universite Paris Descartes,Institut Ntaitonal de la Sante et de la recherche Medicale (INSERM),Assistance Publique—Hopitaux de Paris
- Current Assignee: Centre National de la Recherche Scientifique (CNRS),Universite Paris Descartes,Institut Ntaitonal de la Sante et de la recherche Medicale (INSERM),Assistance Publique—Hopitaux de Paris
- Current Assignee Address: FR Paris FR Paris FR Paris FR Paris
- Agency: Buchanan Ingersoll & Rooney PC
- Priority: EP13306428 20131017
- Main IPC: C12N5/0775
- IPC: C12N5/0775 ; C12N5/0793 ; G01N33/50
Abstract:
The present invention relates to a method for in vitro differentiation of a population of blood circulating cells, such as monocytes and preferably pluripotent macrophages derived therefrom, into cells displaying functional and phenotypic neuronal characteristics. The invention further encompasses neuronal-like cells obtainable according to the present method, compositions comprising said cells, and applications thereof.
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