Invention Grant
- Patent Title: Compositions and methods for inhibiting gene expression of LPA
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Application No.: US15281309Application Date: 2016-09-30
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Publication No.: US09932586B2Publication Date: 2018-04-03
- Inventor: Stacey Melquist , Steven Kanner , David B. Rozema , David L. Lewis , Lauren J. Almeida , Darren H. Wakefield , Vladimir S. Trubetskoy , Tao Pei , Zhen Li , Aaron Almeida
- Applicant: Arrowhead Pharmaceuticals, Inc.
- Applicant Address: US CA Pasadena
- Assignee: Arrowhead Pharmaceuticals, Inc.
- Current Assignee: Arrowhead Pharmaceuticals, Inc.
- Current Assignee Address: US CA Pasadena
- Agency: Amgen Inc.
- Agent Angela L. Purcell
- Main IPC: C12N15/113
- IPC: C12N15/113 ; A61K31/7105 ; A61K31/7115 ; A61K31/712 ; A61K31/7125 ; A61K31/713
Abstract:
RNA interference (RNAi) agents and RNAi agent conjugates for inhibiting the expression of the LPA (apo(a)) gene are described. Pharmaceutical compositions comprising one or more LPA RNAi agents optionally with one or more additional therapeutics are also described. Delivery of the described LPA RNAi agents to liver cells in vivo provides for inhibition of LPA gene expression and treatment of cardiovascular and cardiovascular-related diseases.
Public/Granted literature
- US20170096665A1 Compositions and Methods for Inhibiting Gene Expression of LPA Public/Granted day:2017-04-06
Information query
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