Invention Grant
- Patent Title: Ketoreductase polypeptides for the production of (R)-3-hydroxythiolane
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Application No.: US15184018Application Date: 2016-06-16
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Publication No.: US09932615B2Publication Date: 2018-04-03
- Inventor: Jack S Liang , Stephan Jenne , Emily Mundorff , Rama Voladri , James J. Lalonde , Gjalt W. Huisman
- Applicant: Codexis, Inc.
- Applicant Address: US CA Redwood City
- Assignee: Codexis, Inc.
- Current Assignee: Codexis, Inc.
- Current Assignee Address: US CA Redwood City
- Agency: Codexis, Inc.
- Main IPC: C12N9/02
- IPC: C12N9/02 ; C12N9/04 ; C12P17/00 ; C12P21/06 ; C07H21/04 ; C07K1/00 ; C12P17/16
Abstract:
The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize chiral compounds.
Public/Granted literature
- US20160289717A1 KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF (R)-3-HYDROXYTHIOLANE Public/Granted day:2016-10-06
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