Invention Grant
- Patent Title: Modulators for Sirt5 and assays for screening same
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Application No.: US13808706Application Date: 2011-07-07
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Publication No.: US09932621B2Publication Date: 2018-04-03
- Inventor: Hening Lin
- Applicant: Hening Lin
- Applicant Address: US NY Ithaca
- Assignee: CORNELL UNIVERSITY
- Current Assignee: CORNELL UNIVERSITY
- Current Assignee Address: US NY Ithaca
- Agency: Scully Scott Murphy & Presser
- International Application: PCT/US2011/043130 WO 20110707
- International Announcement: WO2012/006391 WO 20120112
- Main IPC: C12Q1/37
- IPC: C12Q1/37 ; A61K31/197 ; C12Q1/25 ; C12Q1/34 ; C07D239/56 ; C07D233/70 ; C07D233/80 ; C07D233/84 ; C07D233/90 ; C07D235/04 ; C07D401/06 ; C07D405/06 ; C07D409/04 ; C07D239/70 ; C07D243/04 ; C07D471/04 ; C07D491/052 ; C07D495/04 ; C07D513/04 ; C07D285/24 ; C07K7/06 ; C07K14/47 ; A61K38/00
Abstract:
Sirt5, a mitochondrial Sirtuin, has been identified herein as an efficient demalonylase and desuccinylase. Disclosed herein are assays to identify Sirt5 modulators based on this robust enzymatic activity. Sirt5-specific modulators can be used study the biological function of Sirt5 and to target Sirt5 activities in treating human diseases.
Public/Granted literature
- US20150057236A1 MODULATORS FOR SIRT5 AND ASSAYS FOR SCREENING SAME Public/Granted day:2015-02-26
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