- Patent Title: System and method for iterative detection of biological molecules
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Application No.: US14820875Application Date: 2015-08-07
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Publication No.: US09933431B2Publication Date: 2018-04-03
- Inventor: Jia Guo
- Applicant: Jia Guo
- Applicant Address: US AZ Scottsdale
- Assignee: Arizona Board of Regents on behalf of Arizona State University
- Current Assignee: Arizona Board of Regents on behalf of Arizona State University
- Current Assignee Address: US AZ Scottsdale
- Agency: Quarles & Brady LLP
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; G01N33/58
Abstract:
A system for the iterative detection of biological molecules includes a probe, and a fluorophore tethered to the probe with an azide-based linker. The linker is configured to be cleaved in the presence of tris(2-carboxyethyl)phosphine (TCEP), and the on/off ratio between a signal measured before treatment with TCEP and a signal measured after treatment with TCEP is at least about 20:1.
Public/Granted literature
- US20160054308A1 SYSTEM AND METHOD FOR ITERATIVE DETECTION OF BIOLOGICAL MOLECULES Public/Granted day:2016-02-25
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