The invention provides a color filter array substrate and a manufacturing method thereof, and a display device. Multiple pixel units arranged in an array are formed on a base of the color filter array substrate, and each pixel unit includes a transparent region and an opaque region located at the periphery of the transparent region, the pixel unit further includes a color filter pattern and a black matrix pattern. The color filter pattern covers the transparent region, and the black matrix pattern directly covers the opaque region in the case of the color filter pattern being not disposed therebelow. Compared with the prior art, the invention can form a thicker black matrix pattern in the opaque region of the pixel unit to thereby prevent the light leakage problem, so that subsequent display quality can be improved.