An example image layout and display navigator system includes a navigator that includes a miniature layout representation corresponding to the layout of images on the display. The navigator is to appear on the display based on user action with respect to displayed content and to allow a user to select an image series via the miniature layout and to select one or more series level operations for application to the image series via the miniature layout. The navigator is to apply a selected series level operation to the image series via the miniature layout based on user input. An action in one of the navigator and the display is to translate into a corresponding action on the other of the navigator and the display. The content display manager is to update the content displayed to reflect the selected series level operation applied to the image series.