Dynamic interface management for interference mitigation is disclosed. In one aspect, an integrated circuit (IC) is provided that employs a control system configured to mitigate electromagnetic interference (EMI) caused by an aggressor communications bus. The control system is configured to receive information related to EMI conditions and adjust a data/clock mode of an interface corresponding to the aggressor communications bus. In this manner, the interface is configured to couple to the aggressor communications bus. The interface is configured to transmit signals to and receive signals from the aggressor communications bus. The control system is configured to use the information related to the EMI conditions to set the data/clock mode of the interface to mitigate the EMI experienced by a victim receiver. Thus, the control system provides designers with an additional tool that may reduce performance degradation of the victim receiver attributable to EMI.