Systems for associating audio files with cells of a spreadsheet are provided. Both audio files and data may be associated with a single cell of the spreadsheet. An audio file may be recorded, retrieved from storage, or converted from a document (e.g., using text-to-speech technology) for association with a spreadsheet. Upon association, audio parameters may be viewed and/or manipulated by a user, providing audio processing functionality within a spreadsheet. Controls may be provided for listening to the audio file and/or playing the audio file in response to spreadsheet data satisfying a condition. Text transcriptions (e.g., speech-to-text) of audio files may be inserted into the spreadsheet. For low vision users, audio transcriptions (e.g., text-to-speech) of data may be generated and “played” for the user. Spreadsheet operations (e.g., sort and/or filter operations) may also be performed on a range of cells based on audio parameters of associated audio files.