A pixel structure includes pixel electrodes, data lines, and gate lines. Each of the pixel electrodes has two opposite ends that are each provided with one of the gate lines. The data lines and the gate lines re perpendicular to each other. Each of the pixel electrodes includes at least two sub-pixel domains. The data lines are located beneath the pixel electrode at interfacing between every two adjacent ones of the sub-pixel domains. The pixel electrodes each include slits located in the interfacing of the two adjacent sub-pixel domains. The slits are in alignment with the data line and located above the data line. Also provided is a liquid crystal display. The pixel structure and a liquid crystal display including the pixel structure have a reduced overlapping area between the data line and the pixel electrode above the data line so as to reduce parasitic capacitance and improve V-crosstalk.