A front-end module configured to cancel unwanted transmit spectrum at one or more receivers comprises at least one transmitter having a power amplifier and configured to transmit signals to an antenna. The front-end module also comprises at least one receiver to receive the transmit signals, wherein the at least one receiver receives at least a portion of unwanted transmit spectrum. A directional coupler couples at least a portion of a transmit output signal from the power amplifier to provide a coupled transmit output signal to signal conditioning circuitry associated with the at least one receiver and configured to condition the coupled transmit output signal to generate a conditioned transmit signal to provide to the at least one receiver, wherein the conditioned transmit signal at least partially cancels the unwanted transmit spectrum. The signal conditioning circuitry may adjust the amplitude and phase of the coupled transmit output signal.