Systems and methods are provided for handling interference during communication of signals. A control signal based on leakage between the transmit path and the receive path, at least one signal applied in the transmit path during transmission of signals, and at least one signal generated in the receive path during processing of received signals. The control signal may then be applied into the receive path for use in completing processing of the received signals. One or more characteristics associated with the control signal may be set and/or adjusted based on one or more control signals applied in the transmit path. Characteristics of signals in the transmit path that may leak into the receive path may be tracked, and the control signal may be adjusted based on these Characteristics. Transmit power may be tracked, and the control signal may be adjusted based on the tracking of the transmit power.