Methods and apparatuses pertaining to opportunistic peak-to-average power ratio reduction in multi-user multi-input and multi-output (MU-MIMO) wireless communication are described. A method may involve determining whether a length of a payload of each spatial stream of a plurality of spatial streams is less than a predetermined length for transmission of each spatial stream of the plurality of spatial streams. The method may also involve padding one or more time slots associated with a first spatial stream of the plurality of spatial streams with one or more special symbols other than zero in response to a determination that the length of a first payload of the first spatial stream is less than the predetermined length. The method may further involve transmitting the first spatial stream which includes the first payload and the one or more special symbols.