A method of correcting pixel non-uniformity for varying temperature includes determining an FPA temperature and calculating a non-uniformity correction map on a pixel by pixel basis for the FPA, wherein the non-uniformity correction for each pixel is a function of the FPA temperature and empirically derived coefficients. The method also includes applying the non-uniformity correction map at the FPA temperature to condition output of the FPA to produce temperature dependent non-uniformity corrected image data. An imaging system includes a focal plane array (FPA). A temperature sensor is operatively connected to measure FPA temperature. A module is operatively connected to the FPA and temperature sensor to calculate and apply a non-uniformity correction map as described above. There need be no temperature control device for the FPA. The FPA can include a buffered current mirror pixel architecture, and can include an InGaAs material for infrared imaging.