A method for processing, by a gateway, an X2 message in a wireless communication system, the method includes receiving, by the gateway, an X2 setup request message and first target information from a first eNodeB (eNB); transmitting, by the gateway, the received X2 setup request message to a second eNB based on the received first target information; receiving, by the gateway, an X2 setup response message and second target information from the second eNB; and transmitting, by the gateway, the received X2 setup response message to the first eNB based on the received second target information.