Invention Grant
- Patent Title: Bone substitute nanocomposites and methods of synthesis using multiphosphorylated peptides
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Application No.: US14943479Application Date: 2015-11-17
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Publication No.: US09937279B2Publication Date: 2018-04-10
- Inventor: Elia Beniash , Charles S. Sfeir
- Applicant: UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
- Applicant Address: US PA Pittsburgh
- Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
- Current Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
- Current Assignee Address: US PA Pittsburgh
- Agency: Eckert Seamans Cherin & Mellott, LLC
- Agent Carol A. Marmo
- Main IPC: A61K38/10
- IPC: A61K38/10 ; A61K38/16 ; C01F5/00 ; A61L27/28 ; A61L27/22 ; C07K14/47 ; C07K7/08 ; A61L27/46 ; A61L27/54 ; A61L27/24 ; A61L27/48 ; C07K14/00 ; A61K38/00
Abstract:
The invention relates to peptides including DEDE(SSD)nDEG indicated by SEQ NO. 1, RRRDEDE(SSD)nDEG indicated by SEQ NO. 2, RRRGDEDE(SSD)nDEG indicated by SEQ NO. 3, and LKKLKKLDEDE(SSD)nDEG indicated by SEQ NO. 4, wherein n is an integer from 2 to 20. The invention also relates to phosphorylating these peptides at multiple amino acid sites by employing casein kinases. These phosphorylated peptides may be used in various applications such as forming mineralized collagen fibrils and biomimetic composites for use in tissue repair and regeneration.
Public/Granted literature
- US20160067376A1 BONE SUBSTITUTE NANOCOMPOSITES AND METHODS OF SYNTHESIS USING MULTIPHOSPHORYLATED PEPTIDES Public/Granted day:2016-03-10
Information query
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