Invention Grant
- Patent Title: Process for manufacturing pyrimidine sulfamide derivatives
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Application No.: US15118046Application Date: 2015-02-13
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Publication No.: US09938244B2Publication Date: 2018-04-10
- Inventor: Stefan Abele , Jacques-Alexis Funel , Ivan Schindelholz
- Applicant: IDORSIA PHARMACEUTICALS LTD
- Applicant Address: CH Allschwil
- Assignee: IDORSIA PHARMACEUTICALS LTD
- Current Assignee: IDORSIA PHARMACEUTICALS LTD
- Current Assignee Address: CH Allschwil
- Agency: Arent Fox LLP
- Priority: EP14155137 20140214
- International Application: PCT/EP2015/053047 WO 20150213
- International Announcement: WO2015/121397 WO 20150820
- Main IPC: C07D239/56
- IPC: C07D239/56 ; C07D401/12 ; C07D239/34

Abstract:
The invention relates to a process for manufacturing the compound of formula I wherein R is H, (C1-C6)alkyl or benzyl, or a salt thereof, said process comprising the reaction of the compound of formula I-1 wherein X is Br, Cl or F, or a salt thereof, with the compound of formula I-2 wherein R is H, (C1-C6)alkyl or benzyl, or a salt thereof, in the presence of a base, and, when X is Br or Cl, in the presence of tetra-n-butyl ammonium fluoride hydrate or cesium fluoride. The invention further relates to the compound of formula I-1 and uses thereof.
Public/Granted literature
- US20160368882A1 PROCESS FOR MANUFACTURING PYRIMIDINE SULFAMIDE DERIVATIVES Public/Granted day:2016-12-22
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