Invention Grant
- Patent Title: Carbonyl erastin analogs and their use
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Application No.: US15111144Application Date: 2015-01-14
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Publication No.: US09938245B2Publication Date: 2018-04-10
- Inventor: Brent R. Stockwell , Wan Seok Yang , Marie-Helene Larraufie
- Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- Applicant Address: US NY New York
- Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- Current Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- Current Assignee Address: US NY New York
- Agency: Bryan Cave LLP
- International Application: PCT/US2015/011451 WO 20150114
- International Announcement: WO2015/109009 WO 20150723
- Main IPC: A61K31/535
- IPC: A61K31/535 ; C07D239/91 ; C07D239/88 ; C07D403/10
Abstract:
The present invention provides, inter alia, compounds having the structure of formula (I): Compositions containing such compounds are also provided. Methods for using such compounds or compositions for treating or ameliorating the effects of a cancer having a cell that harbors an oncogenic RAS mutation, for modulating a lipoxygenase in a ferroptosis cell death pathway, and for depleting reduced glutathione (GSH) in a cell harboring an oncogenic RAS mutation are further provided.
Public/Granted literature
- US20160332974A1 CARBONYL ERASTIN ANALOGS AND THEIR USE Public/Granted day:2016-11-17
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