Hydrazine compound as blood coagulation factor Xa inhibitor
Abstract:
Provided is a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein X is selected from a 3-9 membered carbon ring or a ring which is formed by 3-9 membered carbocyclic ring fused with benzo ring, and a 4-10 membered heterocyclic ring or a ring which is formed by 4-10 membered heterocyclic ring fused with benzo ring; Y and Z are independently selected from 4-9 membered saturated heterocyclic rings respectively; R1-3 are independently selected from H, F, Cl, Br, I, CN, OH, SH, NH2, CHO, COOH respectively, or selected from the group, optionally substituted by R01, consisting of C1-10 alkyl, C1-10 heteroalkyl, C3-10 cyclohydrocarbyl, C3-10 heterocyclohydrocarbyl, C1-10 alkyl substituted by C3-10 cyclohydrocarbyl or C3-10 heterocyclohydrocarbyl, and C1-10 heteroalkyl substituted by C3-10 cyclohydrocarbyl or C3-10 heterocyclohydrocarbyl. The compound can be used as an anticoagulant for treating and preventing thrombotic disorders, and can meet the real needs of selectivity and a potent inhibitor for coagulation Xa.
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