Invention Grant
- Patent Title: Hydrazine compound as blood coagulation factor Xa inhibitor
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Application No.: US15312901Application Date: 2015-05-18
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Publication No.: US09938272B2Publication Date: 2018-04-10
- Inventor: Zhaozhong Ding , Guanghua Lai , Shuhui Chen , Xiaobing Yan
- Applicant: NORTH CHINA PHARMACEUTICAL COMPANY., LTD.
- Applicant Address: CN Shijiazhuang
- Assignee: North China Pharmaceutical Company., Ltd.
- Current Assignee: North China Pharmaceutical Company., Ltd.
- Current Assignee Address: CN Shijiazhuang
- Agency: Harness, Dickey & Pierce, PLC
- Priority: CN201410220616 20140522; CN201510240445 20150512
- International Application: PCT/CN2015/079142 WO 20150518
- International Announcement: WO2015/176625 WO 20151126
- Main IPC: C07D471/04
- IPC: C07D471/04 ; C07D413/14

Abstract:
Provided is a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein X is selected from a 3-9 membered carbon ring or a ring which is formed by 3-9 membered carbocyclic ring fused with benzo ring, and a 4-10 membered heterocyclic ring or a ring which is formed by 4-10 membered heterocyclic ring fused with benzo ring; Y and Z are independently selected from 4-9 membered saturated heterocyclic rings respectively; R1-3 are independently selected from H, F, Cl, Br, I, CN, OH, SH, NH2, CHO, COOH respectively, or selected from the group, optionally substituted by R01, consisting of C1-10 alkyl, C1-10 heteroalkyl, C3-10 cyclohydrocarbyl, C3-10 heterocyclohydrocarbyl, C1-10 alkyl substituted by C3-10 cyclohydrocarbyl or C3-10 heterocyclohydrocarbyl, and C1-10 heteroalkyl substituted by C3-10 cyclohydrocarbyl or C3-10 heterocyclohydrocarbyl. The compound can be used as an anticoagulant for treating and preventing thrombotic disorders, and can meet the real needs of selectivity and a potent inhibitor for coagulation Xa.
Public/Granted literature
- US20170152259A1 HYDRAZINE COMPOUND AS BLOOD COAGULATION FACTOR Xa INHIBITOR Public/Granted day:2017-06-01
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