Invention Grant
- Patent Title: Amino acid sequence presenting fusion polypeptide and its use
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Application No.: US14877475Application Date: 2015-10-07
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Publication No.: US09938340B2Publication Date: 2018-04-10
- Inventor: Herbert Andres , David Casagolda Vallribera , Hartmut Duefel , Michael Gerg , Christian Scholz , Michael Schraeml
- Applicant: HOFFMANN-LA ROCHE INC.
- Applicant Address: US NJ Little Falls
- Assignee: HOFFMANN-LA ROCHE INC.
- Current Assignee: HOFFMANN-LA ROCHE INC.
- Current Assignee Address: US NJ Little Falls
- Agency: Jones Day
- Priority: EP11164957 20110505; EP12155742 20120216
- Main IPC: C07K16/22
- IPC: C07K16/22 ; C12N9/90 ; C07K16/12 ; G01N33/74 ; C07K16/40 ; G01N33/573 ; C07K14/475 ; C07K14/65

Abstract:
Herein is reported a fusion polypeptide according to formula I NH2—S2—X1—S1—COOH (formula I) wherein X1 comprises either a random amino acid sequence or an amino acid sequence derived from a first polypeptide, S2 and S1 are non-overlapping amino acid sequences derived from a second polypeptide, and — denotes a peptide bond, wherein the second polypeptide is a polypeptide with peptidyl-prolyl cis/trans-isomerase activity (PPIase activity) or is derived from the FKBP-fold domain family, wherein X1 is inserted in place of the insert-in-flap-domain of the second polypeptide.
Public/Granted literature
- US20160138004A1 Amino Acid Sequence Presenting Fusion Polypeptide And Its Use Public/Granted day:2016-05-19
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