Invention Grant
- Patent Title: Lin28-mediated control of let-7 biogenesis
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Application No.: US14269041Application Date: 2014-05-02
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Publication No.: US09938354B2Publication Date: 2018-04-10
- Inventor: Richard I. Gregory , Elena Piskounova , Dimitrios Iliopoulos
- Applicant: Children's Medical Center Corporation , Dana-Farber Cancer Institute, Inc.
- Applicant Address: US MA Boston US MA Boston
- Assignee: Dana-Farber Cancer Institute, Inc.,Children's Medical Center Corporation
- Current Assignee: Dana-Farber Cancer Institute, Inc.,Children's Medical Center Corporation
- Current Assignee Address: US MA Boston US MA Boston
- Agency: Wolf, Greenfield & Sacks, P.C.
- Main IPC: A61K31/713
- IPC: A61K31/713 ; C12N15/113 ; C07K16/40 ; A61K31/7105 ; C12N15/11 ; C07K2/00 ; C12N15/115
Abstract:
The present embodiments provide for compositions and methods that regulate microRNA-binding protein-mediated miRNA biogenesis; for example Lin28-mediated biogenesis of let-7; and in particular Lin28A-recruited 3′ terminal uridylyl transferase (TUTase) uridylation of pre-let-7. A particular embodiment provide compositions and methods for screening for agents that inhibit TUTase-dependent Lin28A-mediated repression of let-7 miRNA.
Public/Granted literature
- US20140328858A1 LIN28-MEDIATED CONTROL OF LET-7 BIOGENESIS Public/Granted day:2014-11-06
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