Invention Grant
- Patent Title: Biocatalysts and methods for the synthesis of armodafinil
-
Application No.: US15698319Application Date: 2017-09-07
-
Publication No.: US09938509B2Publication Date: 2018-04-10
- Inventor: Ee Lui Ang , Oscar Alvizo , Behnaz Behrouzian , Michael D. Clay , Steven J. Collier , Ellen D. Eberhard , Fu Fan , Shiwei Song , Derek J. Smith , Magnus Widegren , Robert Wilson , Junye Xu , Jun Zhu
- Applicant: CODEXIS, INC.
- Applicant Address: US CA Redwood City
- Assignee: Codexis, Inc.
- Current Assignee: Codexis, Inc.
- Current Assignee Address: US CA Redwood City
- Agency: Codexis, Inc.
- Main IPC: C12N9/02
- IPC: C12N9/02 ; C12N1/21 ; C12N5/10 ; C12N15/70 ; C12N15/74 ; C12N15/79 ; C12N15/53 ; C12P11/00 ; C12P13/02 ; C12P41/00
Abstract:
The present invention relates to non-naturally occurring polypeptides useful for preparing armodafinil, polynucleotides encoding the polypeptides, and methods of using the polypeptides. The non-naturally occurring polypeptides of the present invention are effective in carrying out biocatalytic conversion of the (i) 2-(benzhydrylsulfinyl)acetamide to (−)-2-[(R)-(diphenylmethyl)sulfinyl]acetamide (armodafinil), or (ii) benzhydryl-thioacetic acid to (R)-2-(benzhydrylsulfinyl)acetic acid, which is a pivotal intermediate in the synthesis of armodafinil, in enantiomeric excess.
Public/Granted literature
- US20180037872A1 BIOCATALYSTS AND METHODS FOR THE SYNTHESIS OF ARMODAFINIL Public/Granted day:2018-02-08
Information query
